148 Sprague–Dawley male rats were used to investigate how NaV1.8 contributes to hyperalgesia induced by anxiety and remifentanil. Created by Jinxia Cai and updated in 2026, the data includes behavioral assessments and molecular measurements of mitochondrial dynamics.
Use Cases
- Correlating NaV1.8 mRNA levels in the dorsal root ganglia with paw withdrawal latency
- Evaluating the effect of AS-NaV1.8 on spinal NR2B and Drp1 protein expression
- Comparing MitoSox-positive cell counts between CARIH and AS-NaV1.8 treatment groups
Strengths
- Includes 148 Sprague–Dawley male rats for experimental consistency
- Integrates behavioral metrics with molecular data like GSH/GSSG ratios and malondialdehyde levels
- Provides longitudinal molecular data with measurements taken at 4-hour and 24-hour intervals
Limitations
- Restricted to male subjects, excluding potential sex-dependent variations in hyperalgesia
- Specific raw data columns and units of measurement are not explicitly documented in the metadata
- Small sample size of 148 subjects limits the power for high-dimensional statistical modeling
Provenance
- Source
- Harvard Dataverse
- Collection Method
- experimental observation