Vosamidines A–C: Polycyclic Alkaloids from a Marine Sponge with Bioactivity Data

Three novel polycyclic 2-aminoimidazole alkaloids, named Vosamidines A–C, were isolated from the marine sponge Vosmaeropsis wilsoni. Their structures were determined using spectroscopic and spectrometric data analysis and ECD computational studies. The dataset, shared by Sarath P. D. Senadeera in April 2026, includes bioactivity results showing modest inhibition of an oncogenic fusion protein kinase by two of the compounds.

Use Cases

• Structure-activity relationship analysis based on the described polycyclic ring systems and bioactivity results.
• Computational chemistry validation based on the ECD studies used for structure determination.
• Biosynthetic pathway modeling based on the proposed pathways for the three alkaloids.
• Marine natural product discovery based on the source organism Vosmaeropsis wilsoni.

Strengths

• Data includes results from a specific bioactivity assay (DNAJB1-PKAcα kinase inhibition).
• Structures were determined using multiple analytical methods (spectroscopic, spectrometric, and computational ECD studies).
• File is provided in a standard, machine-readable format (XLSX).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 16.7 KB, indicating limited scope.

Provenance

Source

Marine calcareous sponge Vosmaeropsis wilsoni.

Collection Method

Isolation and structural determination via spectroscopic/spectrometric analysis and ECD computational studies.

Time Range

null

Freshness

Last updated 2026-04-22 15:34:12; freshness should be verified.

Geography

null