Vosamidines A-C: Polycyclic Alkaloids from a Marine Sponge with Bioassay Data

Marine sponge Vosmaeropsis wilsoni yielded three polycyclic 2-aminoimidazole alkaloids, Vosamidines A–C. Their structures were determined by spectroscopic and spectrometric analysis and ECD computational studies. The dataset, shared by Sarath P. D. Senadeera on figshare in April 2026, includes bioassay results showing modest inhibition of an oncogenic fusion protein kinase for two compounds.

Use Cases

• Structure-activity relationship analysis based on the described polycyclic ring systems and bioassay results.
• Computational chemistry validation based on the ECD computational studies mentioned in the description.
• Biosynthetic pathway modeling based on the proposed pathways for the compounds.
• Marine natural product discovery based on the source organism Vosmaeropsis wilsoni.

Strengths

• Includes spectroscopic and spectrometric data for structure determination.
• Contains bioassay results for inhibition of the DNAJB1-PKAcα kinase.
• Dataset is 12.9 MB, making it a manageable download size.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Isolation from marine sponge and spectroscopic analysis.

Time Range

null

Freshness

Last updated 2026-04-22 15:34:11; freshness should be verified.

Geography

Marine source; specific collection location not stated.