Systematic Review and Network Meta-Analysis of Medications for MS-Related Fatigue

15 studies were included in a systematic review comparing medications for fatigue in multiple sclerosis. The analysis, conducted by Mohsen Rastkar and published in 2026, found Amantadine, Dalfampridine, and Methylphenidate showed statistically significant improvements in fatigue impact compared to placebo. The dataset is a 61.8 KB DOCX document containing the full review.

Use Cases

• Compare the efficacy of different medications for MS-related fatigue based on the reported mean differences and confidence intervals.
• Rank interventions for fatigue impact using the Surface Under the Cumulative Ranking Curve (SUCRA) methodology described.
• Identify gaps in clinical evidence for MS fatigue treatments based on the 15 included studies and comparison to placebo.

Strengths

• Includes specific quantitative results, such as mean differences and 95% confidence intervals for multiple medications.
• Applies a network meta-analysis methodology, allowing for indirect comparisons of interventions not directly studied head-to-head.
• Sources data from five major biomedical databases (PubMed, Scopus, EMBASE, PsycINFO, Web of Science) searched by two independent researchers.

Limitations

• Row count is unknown, which may limit suitability assessment for quantitative re-analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 61.8 KB DOCX file, suggesting a limited scope focused on the review document rather than raw underlying data.

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of literature from PubMed, Scopus, EMBASE, PsycINFO, and Web of Science.

Time Range

Literature search conducted on 1 March 2025.

Freshness

Last updated 2026-05-14 08:01:15; freshness should be verified.

Geography

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