Whole-Body Mouse T1 Mapping with Prospective Cardio-Respiratory Gating

Prospective gating and automatic reacquisition were implemented to enable cardio-respiratory synchronized T1 mapping of the whole mouse in MRI scans. The method, developed by Paul Kinchesh at the University of Oxford, acquired data with a voxel size of 0.075 mm3 and completed scans in less than 14 minutes. The standard deviation in the T1 measurement is conservatively estimated to be less than 6.2%.

Use Cases

• Validate T1 mapping accuracy in small animals based on the described prospective gating and reacquisition method.
• Compare motion artifact reduction techniques based on the described cardio-respiratory (CR) and respiratory (R) gating stability tests.
• Develop efficient nonlinear least squares fitting algorithms for T1 calculation based on the described robust method.
• Optimize MRI scan protocols for small animal imaging based on the described use of 16 flip angles and 32 k-lines per cardiac R-wave.

Strengths

• Voxel size of 0.075 mm3 provides high spatial resolution for small animal imaging.
• Total scan time reported as less than 14 minutes enables faster acquisition.
• Standard deviation in T1 measurement is conservatively estimated to be less than 6.2%.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

University of Oxford

Collection Method

Prospective gating and automatic reacquisition implemented in variable flip angle (VFA) and actual flip angle imaging (AFI) MRI scans.