Brain Methylation Profiles Across Three Life Stages in Rare Minnow

Whole-genome bisulfite sequencing data captures DNA methylation changes in the brain of the rare minnow (Gobiocypris rarus) at 8, 44, and 74 months of age. The dataset contains genome-wide methylation matrices, differentially methylated region results, and summary statistics. It was authored by Yongfeng He and published on figshare in April 2026.

Use Cases

• Identify age-associated differentially methylated regions (DMRs) by comparing methylation matrices across the three time points.
• Analyze genome-wide methylation patterns in brain tissue to study epigenetic regulation of aging.
• Correlate specific DMR results with known gene pathways for functional enrichment analysis.
• Use the provided summary statistics for meta-analysis of epigenetic aging across different species.

Strengths

• Data spans three distinct age stages (8, 44, 74 months) enabling longitudinal epigenetic analysis.
• Includes multiple processed data types: genome-wide methylation matrices, DMR results, and summary statistics.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Dataset is relatively small at 43.6 MB, suggesting it may be a processed subset rather than raw sequencing reads.
• Sample size (number of biological replicates per age group) is unknown, limiting statistical assessment.
• Limited to a single tissue type (brain) from one fish species, reducing generalizability.

Provenance

Source

figshare, authored by Yongfeng He.

Collection Method

Processed data from whole-genome bisulfite sequencing (WGBS) analysis of brain tissues.

Time Range

Samples collected from individuals at 8, 44, and 74 months of age.

Freshness

Last updated in April 2026, indicating recent publication.

Geography

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