WNT2B Non-Secretory Pathway Research Manuscript

A research manuscript by Danqiong Liu, published on figshare in June 2026, details a novel non-secretory function of the WNT2B protein. The 43.1 MB document describes how intracellular WNT2B impairs endosomal trafficking and autophagy, contributing to inflammation and fibrosis, with validation in a mouse colitis model and Crohn's disease patient tissues.

Use Cases

• Analyzing the molecular mechanism of WNT2B's non-secretory function based on the description of its interaction with the WASHC5 protein.
• Studying the link between impaired endosomal trafficking and autophagy defects based on the described WNT2B-WASH-ATG9A regulatory axis.
• Investigating potential therapeutic targets for Crohn's disease based on the correlation between elevated WNT2B, reduced autophagy, and disease severity described in patient tissues.
• Exploring non-canonical protein secretion pathways based on the described LC3B-II-dependent autophagic secretion mechanism for WNT2B.

Strengths

• Document is 43.1 MB, suggesting substantial textual content.
• License is CC-BY-4.0, permitting broad reuse with attribution.
• Research includes validation in a TNBS-induced mouse model of chronic colitis and correlation with Crohn's disease patient tissues.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data format is DOCX, which may require conversion for computational analysis.

Provenance

Source

figshare

Freshness

Last updated 2026-06-03 13:00:06; freshness should be verified.