Wubie Fanchun Formula-inducible metabolites in primary ovarian insufficiency model mice th

A metabolomics dataset from a study investigating the therapeutic effects of Wubie Fanchun Formula (WBFC) on premature ovarian insufficiency (POI). Yun Chen authored this dataset, which includes results from LC-TOF-MS analysis identifying 25 bioactive constituents and untargeted metabolomics identifying key metabolites like phosphatidylinositol 38:5 and glutamine. The data was last updated on May 12, 2026.

Use Cases

• Identify potential therapeutic metabolites for ovarian dysfunction based on the metabolomics results.
• Validate network pharmacology predictions using the identified chemical constituents and pathway activation data.
• Study the relationship between systemic metabolic parameters and ovarian function using the described metabolic dysfunction characterizations.
• Investigate the PI3K/AKT/FOXO3a signaling pathway activation in a POI model based on the described experimental results.

Strengths

• The dataset is derived from a study that identified 25 bioactive constituents in the Wubie Fanchun Formula.
• Functional validation was performed through exogenous supplementation of key metabolites, phosphatidylinositol 38:5 and glutamine.
• The dataset is licensed under CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (2.8 MB), which may indicate limited scope or detail.

Provenance

Source

figshare

Collection Method

LC-TOF-MS analysis and untargeted metabolomics on a 4-VCD-induced POI mouse model.

Freshness

Last updated 2026-05-12 17:35:36; freshness should be verified.