XII MN Histology: Hypoglossal Motor Neuron Images from Young and Old Rats

Histology images of hypoglossal motor neurons from Fischer 344 rats, collected using Golgi-Cox and serial block-face scanning electron microscopy (SBFSEM). The dataset, created by Matthew Fogarty and published in 2026, is 9.1 GB in size and contains TIF files. It compares dendritic, spine, and mitochondrial morphology in young (6-month) and old (24-month) rats of both sexes.

Use Cases

• Quantifying age-related dendritic regression based on Golgi-Cox staining images
• Analyzing dendritic spine loss in motor neurons based on microscopy data
• Measuring mitochondrial volume density and fragmentation in dendrites based on SBFSEM images
• Correlating neuronal structural pathology with age-related motor deficits described in the study

Strengths

• Dataset size is 9.1 GB, indicating substantial image data.
• Includes data from both female and male Fischer 344 rats at two distinct age points (6 and 24 months).
• Uses two complementary imaging techniques: Golgi-Cox and serial block-face scanning electron microscopy (SBFSEM).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, from authors Christensen, T.A., Fogarty, M.J.

Collection Method

Data gathered via Golgi-Cox staining and serial block-face scanning electron microscopy (SBFSEM) on Fischer 344 rats.

Time Range

Study involves young (6-month) and old (24-month) rats.

Freshness

Last updated 2026-04-16 18:53:18; freshness should be verified.

Geography

Spatial coverage is not specified in the provided metadata.