XPO1 Inhibitor Selinexor Study: Molecular and Functional Data in Acute Myeloid Leukemia

A research dataset from figshare by Chunli Xu, last updated in April 2026, analyzing the role of Exportin 1 (XPO1) in acute myeloid leukemia. It includes results from public AML datasets, patient samples, and functional assays investigating the mechanism of the XPO1 inhibitor Selinexor. The dataset, approximately 628 KB in size, contains files in DOCX and XLSX formats.

Use Cases

• Analyze the correlation between XPO1 expression and patient prognosis based on clinical data mentioned in the description
• Investigate the suppression of homologous recombination pathways based on BRCA1 and RAD51 downregulation data
• Model drug synergy between Selinexor and Mitoxantrone based on combined effect analysis results
• Study the nuclear retention of the E2F7 transcriptional repressor based on subcellular fractionation assays

Strengths

• Includes data from public AML datasets and patient samples, providing clinical relevance
• Contains results from multiple assay types, including transcriptomic analysis, immunoprecipitation, and DNA damage assays
• Released under a permissive CC-BY-4.0 license for broad reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 628.2 KB size indicates a limited scope, likely containing summary or processed results rather than raw high-throughput data

Provenance

Source

figshare

Collection Method

Analysis of public datasets and original experimental results from functional assays, transcriptomics, and drug interaction studies.

Time Range

null

Freshness

Last updated 2026-04-24 06:44:48; freshness should be verified

Geography

null