Zwitterionic Manganese Porphyrin MRI and SOD Activity Data

Yangjin Dong's research data evaluates zwitterionic manganese(III) porphyrins as dual-functional agents for MRI contrast and superoxide dismutase mimicry. The dataset contains in vitro and in vivo measurements, including relaxivity values of 8–9 mM⁻¹s⁻¹ at 1.41 T, from an acute kidney injury murine model. It supports the analysis of biocompatibility, cytotoxicity, and cellular uptake for combined diagnostic and therapeutic applications.

Use Cases

• Analyze relaxivity (8–9 mM⁻¹s⁻¹) and SOD-like activity correlations from in vitro evaluations of zwitterionic complexes.
• Model the relationship between charge character (cationic/anionic/zwitterionic) and MRI contrast efficacy or antioxidant activity.
• Compare cytotoxicity and cellular uptake data across different manganese porphyrin designs to assess balanced charge mitigation.
• Validate the dual-functional performance of Zwitterionic MnT-4-PyP-COOH using data from the lipopolysaccharide-induced acute kidney injury model.

Strengths

• Includes specific, quantitative relaxivity measurements of 8–9 mM⁻¹s⁻¹ at 1.41 T for the synthesized complexes.
• Data is derived from both in vitro evaluations and a controlled in vivo murine model of acute kidney injury.
• Focuses on a novel, rationally designed zwitterionic compound addressing a known 'charge contradiction' in the field.

Limitations

• The dataset is very small at 1.8 KB, indicating limited scope and likely a summary of key results rather than raw experimental data.
• Specific sample sizes, row counts, and detailed column structures for statistical analysis are not provided.
• Findings are specific to a single acute kidney injury model, limiting generalizability to other disease contexts.

Provenance

Source

Yangjin Dong via figshare.

Collection Method

Experimental data from the synthesis and evaluation of zwitterionic manganese(III) porphyrins, including in vitro assays and in vivo murine studies.

Freshness

Last updated March 2026.