Aptamer-Modified Nanoparticle Data for Domoic Acid Toxicity Alleviation

A 483.8 KB dataset from figshare, last updated April 13, 2026, containing experimental results on biomimetic nanoparticles. The data, authored by xinyue gan, details the construction and performance of aptamer-modified neuronal cell membrane hybrid liposomes (A-H@L) for adsorbing the marine neurotoxin domoic acid. It includes in vitro and in vivo findings on cytotoxicity mitigation, oxidative stress inhibition, and calcium homeostasis restoration in cell lines and zebrafish larvae.

Use Cases

• Modeling nanoparticle adsorption capacity for domoic acid based on the described aptamer modification.
• Analyzing cytotoxicity mitigation in Caco-2 and BV2 cell lines based on the described in vitro studies.
• Investigating neurotoxicity alleviation mechanisms based on described ATPase activity and calcium homeostasis data.
• Studying gene expression dysregulation (Atp2a2a, Ryr2b) in zebrafish larvae based on the described in vivo investigations.

Strengths

• Data is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• File size is precisely 483.8 KB, indicating a focused and manageable dataset.
• The description provides specific experimental details on nanoparticle construction, cell lines, and mechanistic pathways.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (483.8 KB), indicating a limited scope focused on a specific experimental study.

Provenance

Source

figshare, author xinyue gan.

Collection Method

Likely contains experimental results from the construction and testing of aptamer-modified biomimetic nanoparticles.

Time Range

The study's temporal coverage is not specified in the provided metadata.

Freshness

Last updated 2026-04-13 12:33:31; freshness should be verified.

Geography

Spatial coverage is not specified in the provided metadata.