<b>Flash Nanoprecipitation for Co-Delivery of Diagnostic Magnetic Nanoparticles and Anti-I

A dataset from figshare by Hannah Pohlit, last updated in May 2026, detailing the formulation and characterization of polymeric nanocarriers. The 1.0 GB collection includes data on nanocarrier dispersions produced by flash nanoprecipitation, encapsulating magnetic nanoparticles and a model anti-inflammatory drug. It contains results on formulation parameters, colloidal stability, MRI contrast properties, and in vitro cytotoxicity assays.

Use Cases

• Optimizing nanoparticle formulation parameters based on data for PLA–PEG molecular weight, solute concentration, and solvent ratios.
• Analyzing pH-responsive disassembly behavior for targeted drug delivery based on stability data at different pH levels.
• Evaluating magnetic resonance imaging (MRI) contrast performance based on measured relaxivity (r2) values.
• Assessing drug encapsulation efficiency and cytotoxicity for nanocarrier safety and efficacy screening.

Strengths

• Includes long-term stability data showing colloidal stability in water at room temperature for up to six months.
• Provides specific measured relaxivity for MRI contrast (r2 = 0.273·(mM−1·ms−1) at 9.4 T).
• Reports hydrodynamic diameters <200 nm with low dispersity (PDI < 25%) for optimized formulations.
• Contains in vitro cytotoxicity results from MTT and crystal violet assays on Caco‑2 and NIH/3T3 cells.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description notes a low drug encapsulation efficiency (≤5%), indicating a key performance limitation.

Provenance

Source

Hannah Pohlit via figshare

Collection Method

Experimental data from flash nanoprecipitation (FNP) synthesis and subsequent characterization.

Freshness

Last updated 2026-05-04 11:08:54; freshness should be verified.