BioU (K124A) Crystal Structure with NAD+ and Reaction Intermediate Analog

A crystal structure of the suicide enzyme BioU from Synechocystis sp. PCC6803, in complex with NAD+ and a reaction intermediate analog. The dataset was contributed by author Kei Sakaki from The University of Tokyo. The description notes BioU loses the Lys124 amino group after a single catalytic round.

Use Cases

• Analyzing enzyme-substrate interactions based on the described co-crystal structure.
• Studying suicide enzyme mechanisms based on the described loss of the Lys124 amino group.
• Modeling protein-ligand binding for the NAD+ cofactor and reaction intermediate analog.

Strengths

• The dataset is associated with a specific, described biological mechanism (suicide enzyme activity).
• The author and organization (Kei Sakaki, The University of Tokyo) are identified.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

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