M2 Muscarinic Receptor Crystal Structure with NMS Ligand (Hg-derivative)

Ryoji Suno from Kyoto University determined the crystal structure of a rationally thermostabilized M2 muscarinic acetylcholine receptor. The structure is bound with the antagonist NMS and includes a mercury derivative for phasing. The dataset likely contains atomic coordinates and structural parameters for this G protein-coupled receptor.

Use Cases

• Analyzing receptor-ligand interactions based on the bound NMS antagonist structure.
• Studying the effects of rational thermostabilization on GPCR conformation.
• Using the mercury-derivative data for teaching or validating crystallographic phasing methods.
• Comparing the M2 receptor structure to other muscarinic receptor subtypes for selectivity analysis.

Strengths

• Structure determined by a researcher from Kyoto University, a reputable institution.
• Focuses on a rationally thermostabilized protein, a specific and engineered construct.
• Includes a mercury derivative, a specific experimental detail for crystallography.

Limitations

• Row count and dataset size are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Ryoji Suno, Kyoto University, via paperswithcode.

Collection Method

Likely derived from X-ray crystallography experiments.