Polymer-Shelled Microbubbles with Iron Oxide Nanoparticles for Dual-Mode Imaging

29% SPION density relative to microbubble mass was successfully tested for optimal dual-mode contrast. The dataset contains in vitro experimental results from static and dynamic tests assessing two dual-mode contrast agents for simultaneous MRI and ultrasound imaging. It was authored by Claudia Sciallero and published in 2020.

Use Cases

• Analyze the relationship between SPION density and MRI contrast improvement versus UI contrast worsening.
• Compare the performance of microbubbles with externally anchored SPIONs versus those with SPIONs physically entrapped in the shell.
• Evaluate imaging techniques and setup parameters for detecting contrast agents under low-field MRI (0.25 T) and low-peak-pressure UI (<320 kPa) conditions.

Strengths

• Data is derived from controlled in vitro experiments with a defined microbubble concentration of 10^6 bubbles ml^-1.
• Specifics on experimental conditions are provided, including a magnetic flux density of 0.25 T and a UI peak pressure lower than 320 kPa.
• The dataset focuses on a precise and novel biomedical application: polymer-shelled microbubbles loaded with iron oxide nanoparticles for dual-mode imaging.

Limitations

• The dataset scope is limited to in vitro experiments, lacking in vivo validation or clinical data.
• Sample size and specific data volume (rows, columns) are unknown, limiting assessment of statistical power.
• Data is from 2020 and may not reflect the latest advancements in contrast agent or imaging technology.

Provenance

Source

Dryad digital repository.

Collection Method

In vitro static and dynamic experiments with polymer-shelled microbubbles under specified MRI and ultrasound conditions.

Freshness

Last updated 2020-06-24.