Calcium Sulfide Nanoparticle Neuroprotection Study in Ischemic Stroke Mouse Model

A 1.6 MB research document details the synthesis and testing of calcium sulfide nanoparticles as a sustained hydrogen sulfide donor for neuroprotection. The study includes in vitro results from SH-SY5Y and BV2 cell lines and in vivo results from a distal middle cerebral artery occlusion mouse model, showing reduced infarct area and improved neurological scores. The dataset, authored by Zhen Lu and last updated on 2026-04-17, is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Analyzing sustained H2S release profiles based on nanoparticle characterization data
• Modeling neuroprotective efficacy based on cell viability and apoptosis markers from OGD/R experiments
• Studying anti-inflammatory effects based on cytokine expression levels in microglia
• Evaluating in vivo therapeutic outcomes based on neurological scores and infarct area measurements from the dMCAO model

Strengths

• Documented in vitro and in vivo experimental results, including specific cell lines (SH-SY5Y, BV2) and a mouse model (dMCAO).
• Includes specific quantitative outcomes such as 48-hour H2S release, 24-hour neurological scores, and day-3 infarct area reduction.
• Shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The primary data file is a 1.6 MB DOCX document; underlying raw or structured data is not directly accessible.
• Column-level documentation and sample data are unavailable, requiring manual extraction of information from the text.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare, authored by Zhen Lu.

Collection Method

Data appears to be generated from a wet-chemistry synthesis of nanoparticles and subsequent biological experiments.

Freshness

Last updated 2026-04-17 04:12:16; freshness should be verified.