CBX4 Facilitates EV71 Replication by SUMOylation and Stabilizing 3D Polymerase

A research data sheet from 2026 by Rui Su, shared under a CC-BY-4.0 license on figshare. The document details molecular biology findings on how the SUMO E3 ligase CBX4 promotes Enterovirus 71 replication through post-translational modifications of the viral 3D polymerase. The described regulatory mechanism and inhibitory effect of the compound 2-D08 were also observed in related viruses like coxsackievirus B3 and poliovirus 1.

Use Cases

• Studying host-virus protein interactions based on the described CBX4 and 3D polymerase interaction
• Investigating post-translational modifications in viral replication based on the described SUMOylation and ubiquitination of 3D
• Evaluating potential antiviral compounds based on the described inhibitory effect of 2-D08 on EV71 replication
• Comparative virology research based on the described effect observed in CVB3 and PV1

Strengths

• Shared under a permissive CC-BY-4.0 license
• Focuses on a primary etiological agent of hand-foot-mouth disease in children under 5 years of age
• Describes a regulatory mechanism observed across multiple enteroviruses

Limitations

• Dataset is a 1.5 MB DOCX file; the underlying structured data (e.g., raw experimental measurements) is not directly accessible
• Row count and column-level documentation are absent; data semantics must be inferred from the textual description
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Research data sheet, likely summarizing experimental findings.

Freshness

Last updated 2026-04-13 21:07:09