H-ferritin Nanoparticle-Mediated Antibody Delivery Across the Blood-Brain Barrier

A research document details the generation and evaluation of H-ferritin nanoparticles for delivering monoclonal antibodies across the blood-brain barrier. The study, authored by Ziwei Yuan, includes in vitro and in vivo assessments of structural integrity, target binding, and pharmacokinetics in humanized mouse models. The dataset was last updated on June 3, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing nanoparticle design for blood-brain barrier penetration based on the H-ferritin shuttle platform described.
• Studying pharmacokinetic profiles of conjugated antibodies based on the in vivo evaluation in humanized TfR1 knock-in mice.
• Investigating methods for antibody-nanoparticle conjugation based on the use of the NHS-PEG-Mal linker detailed in the methods.
• Evaluating pharmacodynamic effects of BACE1 inhibition based on the brain tissue analysis results.

Strengths

• The description provides a detailed methodological background for the experimental study.
• The dataset is associated with a specific, recent update date of 2026-06-03.
• The work is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 248.3 KB DOCX file, indicating a very limited scope, likely a single document rather than a large-scale data collection.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, author Ziwei Yuan.

Collection Method

Experimental research involving protein production, chemical conjugation, and in vitro/in vivo assessment in mouse models.

Freshness

Last updated 2026-06-03 06:04:45; freshness should be verified.