Flutamide-Loaded Nanoparticle Characterization for Targeted Colorectal Cancer Therapy

Flutamide-loaded potato starch-chitosan-lactoferrin nanoparticles (FLU-PS-CS-LF-NPs) were characterized for targeted colorectal cancer therapy. The dataset likely contains results from in silico, in vitro, and in vivo biological evaluations, including nanoparticle size, cytotoxicity, and stability data. Siddhi Throat published this research dataset on figshare in April 2026.

Use Cases

• Training models to predict nanoparticle cytotoxicity based on physicochemical properties like size and zeta potential.
• Analyzing relationships between nanoparticle formulation and anti-metastatic activity mentioned in the description.
• Evaluating the correlation between spectroscopic data (FTIR, XRD) and drug entrapment efficiency.
• Studying the impact of nanoparticle characteristics on inhibition of cancer-associated microbiota.

Strengths

• Includes specific, measured nanoparticle properties: diameter of 186.8 ± 63.12 nm and zeta potential of +5.77 ± 1.56 mV.
• Reports concrete biological activity metrics, such as an IC50 of 6.77 μg/mL against HCT-116 cells from an MTT assay.
• Documents a 6-month stability period for the nanoparticle formulation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's 54.6 MB size suggests it is relatively small, potentially limiting the scope of analysis.

Provenance

Source

figshare

Collection Method

Experimental research involving synthesis and biological evaluation of nanoparticles.

Freshness

Last updated 2026-04-28 22:40:08; freshness should be verified.