Experimental data from a research project investigating the effects of Silicon Dioxide Nanoparticles (SiO₂NPs) on human gut microbiota. The dataset includes results from a computer-controlled in vitro gastrointestinal digestion and batch culture fermentation model inoculated with human fecal microbiota, with measurements taken at four time points. It was authored by Zhang, Zihan (Nylah) and last updated in June 2026.
Use Cases
- Modeling dose-response relationships of nanoparticles on microbial communities based on the three applied doses (low, medium, high).
- Analyzing temporal changes in microbial composition based on 16S rRNA sequencing data collected at 0h, 4h, 8h, and 12h.
- Correlating microbial activity with metabolic outputs based on measurements of short-chain fatty acids (SCFAs), branched-chain fatty acids (BCFAs), ammonium concentration, and antioxidant capacity.
- Comparing treatment effects against control groups that received deionized water.
Strengths
- Experimental design includes three physiologically relevant doses (3.15 mg, 63 mg, and 1,260 mg) and a control group.
- Multiple measurement types are described: 16S rRNA sequencing, SCFA/BCFA quantification, ammonium concentration, and antioxidant capacity (FRAP and DPPH).
- Data collection spans four time points (0h, 4h, 8h, and 12h), allowing for temporal analysis.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is derived from an in vitro model, which may not fully replicate in vivo human gut conditions.
Provenance
- Source
- Borealis Harvested Dataverse
- Collection Method
- Generated using a computer-controlled in vitro gastrointestinal digestion and batch culture fermentation model inoculated with human fecal microbiota.
- Freshness
- Last updated 2026-06-20 04:11:55; freshness should be verified.