PTH1R Crystal Structure with Peptide Agonist at 2.5-Å Resolution

A high-resolution crystal structure of the human parathyroid hormone 1 receptor (PTH1R) in complex with a peptide agonist. The dataset, from a study by Janosch Ehrenmann of the University of Zurich, provides atomic-level details of ligand binding and receptor activation mechanisms. It offers structural insight into a class B GPCR relevant to osteoporosis treatment.

Use Cases

• Analyzing peptide agonist binding modes based on the described extracellular and transmembrane domain interactions.
• Modeling class B GPCR activation mechanisms based on the conserved structural motifs detailed in the description.
• Informing structure-based drug design for osteoporosis treatments based on the receptor-ligand complex structure.

Strengths

• Structure resolved at 2.5-Å resolution, providing high atomic detail.
• Focuses on the human PTH1R, a therapeutically important target for osteoporosis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

University of Zurich

Collection Method

Crystallography