Oral Squamous Cell Carcinoma Drug Response in 2D and 3D Patient-Derived Models

A study comparing antitumoral responses to cisplatin and a novel Pt(IV) prodrug in primary patient-derived oral squamous cell carcinoma models. The research, authored by Griso Acevedo, Ana Belén, also tests the delivery and efficacy of these drugs encapsulated in mesoporous silica nanoparticles. Results highlight improved cytotoxicity and p53-dependent apoptotic cell death with the nanoparticle-mediated Pt(IV) compound.

Use Cases

• Compare drug efficacy between cisplatin and Pt(IV) prodrugs based on in vitro cytotoxicity data.
• Evaluate nanoparticle-mediated drug delivery performance based on encapsulation in mesoporous silica nanoparticles.
• Study cisplatin resistance mechanisms based on primary patient-derived 2D and 3D OSCC models.
• Investigate apoptotic pathways based on p53-dependent cell death response data.

Strengths

• Uses primary patient-derived models, which may better represent clinical tumor biology.
• Compares both 2D and 3D in vitro models for drug testing.
• Tests a novel Pt(IV) compound and its nanoparticle-encapsulated form.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

e-cienciaDatos Harvested Dataverse

Collection Method

Likely contains experimental results from in vitro drug testing on patient-derived cancer models.

Freshness

Last updated 2026-05-31 04:10:12; freshness should be verified.