k2/Ks Constants for Penicillin G, Ceftriaxone, and Cefixime Against Mutant PBP2 Proteins

Marissa M. Bivins provides a dataset of k2/Ks constants for three antibiotics—Penicillin G, Ceftriaxone, and Cefixime—against three mutant forms of Penicillin-Binding Protein 2 (PBP2-6M, PBP2-7M, PBP2-10M). The 5.5 KB Excel file was last updated on March 17, 2026. The constants were derived using [14C]benzyl penicillin G as described in referenced literature.

Use Cases

• Modeling antibiotic binding kinetics based on k2/Ks constants for mutant proteins.
• Comparing resistance levels conferred by different PBP2 mutations against beta-lactam antibiotics.
• Analyzing epistatic interactions in evolving cephalosporin resistance based on the mutant set.
• Correlating protein flexibility changes with binding affinity constants.

Strengths

• Provides specific biochemical constants (k2/Ks) for three clinically relevant antibiotics.
• Data is directly linked to cited, peer-reviewed literature sources [24, 37].
• File size is 5.5 KB, ensuring quick download and easy inspection.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset's scope is limited to three antibiotics and three specific PBP2 mutants.

Provenance

Source

figshare, author Marissa M. Bivins.

Collection Method

k2/Ks values were derived using [14C]benzyl penicillin G as described in referenced literature.

Time Range

null

Freshness

Last updated 2026-03-17 17:38:18.

Geography

null