Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Ty

Experimental data from a study investigating the cellular targeting and uptake of DNA origami-based nucleic acid nanoparticles (NANPs) in liver and neuronal cell models. The dataset, shared by Hyun Min Kim on figshare, was last updated in March 2026 and is stored in an 83.2 MB XLSX file. It likely contains results from systematic evaluations of ligand valency, spacing, linker length, and chemistry on nanoparticle association with on- and off-target cell types.

Use Cases

• Optimizing nanoparticle design for liver cell targeting based on ligand valency and spacing data.
• Benchmarking siRNA delivery efficiency of NANPs against lipid nanoparticle technologies.
• Analyzing the role of the biomolecular corona and receptor engagement in nanoparticle uptake.
• Investigating lipid functionalization strategies for targeting non-hepatic cells, such as neuronal models.

Strengths

• Dataset size is 83.2 MB, suggesting a substantial volume of experimental results.
• Focuses on clinically validated receptors (ASGPR and LDLR) and model cell lines (HepG2).
• Systematically evaluates multiple design parameters: ligand valency, interligand spacing, linker length, and ligand chemistry.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is derived from in vitro cell models, which may not fully translate to in vivo conditions.

Provenance

Source

figshare

Collection Method

Experimental data from in vitro cell studies using a rational design approach.

Time Range

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Freshness

Last updated 2026-03 25 23:43:40; freshness should be verified.

Geography

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