Deferoxamine-Loaded Mesoporous Silica Nanoparticles for Neuroprotective Therapy

A nanoformulation study presents mesoporous silica nanoparticles loaded with the metal chelator deferoxamine. The dataset, harvested from e-cienciaDatos by author Mónica Onrubia-Márquez, was last updated on 2026-05-31. It details the synthesis and characterization of nanoparticles designed for enhanced blood-brain barrier permeability and neuroprotection.

Use Cases

• Compare drug loading capacity based on the reported 10 mg of DFO per 100 mg of MSNs
• Analyze drug release profiles based on the sustained release characteristic of less than 20% cargo released over 24 hours
• Investigate the relationship between nanoparticle size and transport efficiency based on permeability studies using an in vitro BBB model
• Evaluate in vitro safety and efficacy based on assays using BV-2 microglial and SH-SY5Y cell lines

Strengths

• Reports a specific drug loading capacity of 10 mg of DFO per 100 mg of MSNs
• Quantifies a sustained release profile with less than 20% of cargo released over 24 hours
• Describes nanoparticle size control below 20 nm

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

e-cienciaDatos Harvested Dataverse

Freshness

Last updated 2026-05-31 04:10:10; freshness should be verified