BP@CS Nanoparticles: In Vitro and In Vivo Efficacy Data for Corneal Injury

Black phosphorus quantum dot-chitosan nanoparticles (BP@CS) demonstrate sustained antioxidant activity to inhibit pathological corneal blood vessel growth in a mouse alkali burn model. Experimental data includes in vitro cytotoxicity, drug release, and antioxidant assays, alongside in vivo imaging, histology (HE, Masson), and protein analysis (immunofluorescence, Western blot). This 953,071-byte dataset supports a novel therapeutic approach using subconjunctival injection for sustained reactive oxygen species regulation.

Use Cases

• Evaluating nanoparticle cytotoxicity and antioxidant capacity based on CCK8 and cell co-culture experiments
• Assessing anti-angiogenic efficacy in vivo based on small animal imaging and front segment photos
• Characterizing nanoparticle physicochemical properties based on TEM, Zeta potential, and Raman spectroscopy data
• Correlating reactive oxygen species levels with neovascularization based on immunofluorescence and Western blot results
• Studying the biosafety and tissue response of subconjunctival injections based on HE and Masson staining

Strengths

• Dataset is openly licensed (CC-BY-4.0), facilitating reuse and redistribution.
• Data integrates multimodal experimental results, from physicochemical characterization to in vivo efficacy and biosafety.
• Research presents a specific, novel therapeutic approach (BP@CS nanoparticles via subconjunctival injection) with supporting evidence.

Limitations

• Column names and row counts are not provided, limiting precise understanding of data structure.
• The dataset's primary file formats (JPG, DOCX) suggest it may contain processed images and documents rather than raw, machine-readable data tables.
• The 'Last updated' date (2026-03-24) is in the future, indicating a metadata error that affects trust in timestamp accuracy.

Provenance

Source

Jilin Zhou

Collection Method

Generated from laboratory experiments including transmission electron microscopy, spectroscopy, cell culture, and a mouse corneal alkali burn model.

Time Range

Experimental period not specified.

Freshness

2026-03 24 11:40:04 (note: this date is in the future)

Geography

Laboratory study; geographic location not specified.