Multi-Omics Data on Silica Nanoparticle and High-Fat Diet Effects on Fatty Liver Disease

A 2.6 MB supplementary document from a 2026 study investigating the combined effect of silica nanoparticles and a high-fat diet on metabolism-associated fatty liver disease (MAFLD). The research, authored by XueYan Zhang and shared under a CC-BY-4.0 license, utilized a multi-omics approach to analyze gut-liver axis dysfunction, microbiota dysbiosis, and riboflavin metabolism perturbations.

Use Cases

• Analyzing correlations between gut microbiota composition and liver metabolite levels based on the described multi-omics results.
• Investigating molecular docking targets for riboflavin metabolism intermediates like FMN and FAD based on the network toxicology findings.
• Studying the synergistic effects of environmental nanoparticles and dietary factors on liver injury markers such as ALT/AST and steatosis.

Strengths

• Data is associated with a detailed, hypothesis-driven research study published in 2026.
• The dataset is openly shared under a permissive CC-BY-4.0 license.
• The research employed a multi-omics approach, suggesting integrated data layers.

Limitations

• The primary data file is a 2.6 MB DOCX document; underlying structured data (e.g., raw omics tables) are not directly accessible.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental study utilizing a multi-omics approach, as described.

Time Range

Study published in 2026.

Freshness

Last updated 2026-05-08 05:54:10.

Geography

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