Case Report on Obinutuzumab Therapy for Severe Anti-GBM Disease

A figshare admin karger published a case report on April 15, 2026, detailing the treatment of a 20-year-old male patient with severe anti-glomerular basement membrane disease. The 22.4 KB document describes the patient's clinical presentation, treatment with plasmapheresis, corticosteroids, cyclophosphamide, and adjunctive Obinutuzumab, and subsequent renal recovery over a 5-month follow-up.

Use Cases

• Analyzing the potential efficacy of B-cell depleting therapies like Obinutuzumab based on the detailed clinical outcome described.
• Studying treatment protocols for severe anti-GBM disease with poor prognostic markers based on the multimodal therapy timeline.
• Reviewing a documented case of antibody clearance and partial renal recovery following adjunctive immunotherapy.

Strengths

• Document is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• Provides specific clinical details: patient age (20), creatinine level (>700 μmol/L), drug dosage (500 mg IV), and follow-up timeline (3 and 5 months).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single case report (22.4 KB), representing a very limited sample size.

Provenance

Source

figshare admin karger

Collection Method

Likely a manually authored clinical case report.

Time Range

Covers a patient case with a 5-month clinical follow-up period.

Freshness

Last updated 2026-04-15 11:55:33; freshness should be verified.

Geography

Geographic coverage of the patient case is not specified.