Brain Iron Deposition in Parkinson's Disease Subtypes

45 Parkinson's disease patients and 23 healthy controls were analyzed using quantitative susceptibility mapping to measure iron levels in 7 brain regions. The study compares tremor-dominant and postural instability/gait difficulty subtypes, finding distinct iron patterns linked to clinical symptoms.

Use Cases

• Train a classifier to distinguish TD from PIGD subtypes using QSM values from the dentate nucleus and other regions.
• Analyze the correlation between dentate nucleus susceptibility and tremor severity scores across the patient cohort.
• Build a predictive model incorporating levodopa equivalent daily dose and regional iron deposition for motor subtype classification.

Strengths

• Includes data from 68 total subjects (45 patients, 23 controls) for comparative analysis.
• Measures quantitative susceptibility mapping values across 7 specific brain regions per subject.
• Findings are statistically grounded, reporting a correlation (rs=0.339, p=0.023) and model AUC of 0.898.

Limitations

• Small sample size of 68 total subjects limits statistical power and generalizability of findings.
• Data is contained in a 386.5 KB DOCX file, indicating a summary document rather than a raw, analyzable dataset.
• Lacks individual-level tabular data; analysis is based on aggregated study results presented in the paper.

Provenance

Source

figshare, authored by Yiting Chen.

Collection Method

Quantitative susceptibility mapping (QSM) analysis of MRI scans from a clinical study.

Time Range

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Freshness

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Geography

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