Platelet-Membrane-Coated Nanoparticle Data for Targeted Thrombolysis

A research document describes a biomimetic nanothrombolytic agent called PNP-rtPA, developed to improve the safety and efficacy of stroke treatment. The dataset, authored by Ziying Feng and last updated in May 2026, likely contains experimental results from in vitro and in vivo mouse models. It details findings on thrombolytic efficacy, neurovascular protection, and pharmacokinetics.

Use Cases

• Evaluating thrombolytic efficacy based on results from an electrical-stimulation-induced carotid thrombosis model
• Assessing neurovascular safety based on metrics for blood-brain barrier disruption and hemorrhagic transformation
• Analyzing pharmacokinetics based on data on prolonged circulation and accumulation in injured cerebrovascular beds
• Comparing treatment outcomes based on measurements of infarct volume, neurological scores, and survival rates

Strengths

• Dataset is associated with a specific, novel biomimetic nanothrombolytic platform (PNP-rtPA)
• Research includes results from multiple experimental models (in vitro clot lysis, carotid thrombosis, MCA occlusion mouse model)
• License is clearly defined as CC-BY-4.0, permitting broad reuse

Limitations

• Dataset size is only 17.0 KB, indicating very limited scope or content
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Likely contains experimental research data from laboratory studies.

Freshness

Last updated 2026-05-11 05:28:35; freshness should be verified