Impact of Glutaraldehyde Cross-Linking on Allergen Polymer Structure and Allergenicity

Sandra Sivill's dataset from 2026 contains experimental results on polymerized allergen extracts. The data likely includes measurements from structural characterization and allergenicity tests for polymers created with five different glutaraldehyde-to-protein ratios. It was published on figshare under a CC-BY-4.0 license.

Use Cases

• Modeling the relationship between cross-linking ratio and polymer size based on NMR and TEM data mentioned in the description
• Analyzing correlations between polymer density and reduced IgE reactivity based on ELISA and MAT results
• Comparing peptide profiles of native and polymerized allergens based on mass spectrometry data

Strengths

• Data is derived from a systematic study using five distinct cross-linking conditions.
• Structural characterization includes multiple methods: SDS-PAGE, NMR, TEM, and mass spectrometry.
• Allergenicity was evaluated through three distinct assays: ELISA, Western blotting, and mast cell activation test.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 75.5 KB, indicating limited scope.

Provenance

Source

Sandra Sivill via figshare

Collection Method

Experimental data from polymerization of pollen extracts from Phleum pratense and Betula verrucosa.

Freshness

Last updated 2026-03-18 07:47:25; freshness should be verified.