Table 2_Cationic nanoparticles with disrupting neutrophil extracellular traps inhibit the

A 13.7 KB DOCX file authored by Zhaoqiang Zhang and last updated on April 22, 2026, containing research data from a study on head and neck squamous cell carcinoma (HNSCC). The study investigates how cationic nanoparticles (cNP) disrupt neutrophil extracellular traps (NETs) to improve the tumor microenvironment and inhibit metastasis, potentially enhancing anti-PD-1 therapy efficacy.

Use Cases

• Analyzing the correlation between NET expression and immune cell infiltration in HNSCC based on histological and bioinformatics analyses described.
• Evaluating the effects of cationic nanoparticles on tumor cell migration and the immunosuppressive tumor microenvironment based on in vitro and in vivo experiments.
• Investigating the synergistic effect of cNP combined with anti-PD-1 therapy on tumor growth and immune cell populations based on the reported results.
• Studying the mechanism by which NET-DNA promotes cancer cell migration via the CCDC25 receptor based on the described experimental approaches.

Strengths

• Data is associated with a specific, peer-reviewed research study on a defined cancer type and therapeutic approach.
• The dataset is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• Includes results from multiple experimental methods, including histology, bioinformatics, in vitro assays, and in vivo models.

Limitations

• The dataset is a 13.7 KB DOCX file, suggesting limited raw data or a summary document rather than a large, structured dataset.
• Column-level documentation and sample data are unavailable, making field semantics and structure unclear before download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Generated from a research study involving histological staining, bioinformatics analysis, in vitro assays (scratch, adhesion, transwell), and in vivo experiments in mouse models.

Time Range

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Freshness

Last updated 2026-04-22 05:35:30; freshness should be verified.

Geography

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