Neuraminidase Crystal Structure from A/Minnesota/11/2010 with B10 Antibody

Crystallographic data for the neuraminidase protein from the A(H3N2) influenza virus strain A/Minnesota/11/2010, complexed with the B10 antibody. The dataset is associated with research from the Centers for Disease Control and Prevention investigating antigenic drift in circulating viruses since 2016. The study identifies specific amino acid mutations impacting antibody binding and vaccine efficacy.

Use Cases

• Analyzing structural changes in neuraminidase based on identified amino acid mutations at residues 245, 247, and 468.
• Studying antibody-antigen interactions based on the conserved epitope overlapping the NA active site.
• Modeling the impact of glycosylation on protein structure based on the introduced N-linked glycosylation site at residue 245.
• Investigating cross-reactivity of antibodies based on the described broad reactivity to pandemic and contemporary virus strains.

Strengths

• Data is derived from X-ray crystallography, a high-resolution structural biology technique.
• Research is associated with the Centers for Disease Control and Prevention, a leading public health institution.
• The description provides specific biological context regarding antigenic drift and key mutations.

Limitations

• Row count and file size are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The license is listed as closed, which may restrict access and usage.

Provenance

Source

paperswithcode

Collection Method

X-ray crystallography