Photoswitchable Latrunculin B Synthesis and Actin Polymerization Inhibition Data

A dataset from 2026 by Antoine Gamet, shared on figshare, details the total synthesis of a photoswitchable version of the compound latrunculin B. The data likely contains results from photophysical property measurements, in vitro actin filament growth inhibition assays, and molecular docking simulations. The 2.6 MB ZIP file is licensed under CC-BY-NC-4.0.

Use Cases

• Analyzing the photophysical properties of photoswitchable compounds based on photostationary states and fatigue resistance.
• Studying the reversible inhibition of actin filament growth based on in vitro assay data comparing Z and E photoisomers.
• Investigating photoinduced control of cell migration and membrane dynamics based on cellular experiment results.
• Validating molecular docking models based on the rationalization of reversible inhibition behavior.

Strengths

• Includes specific photophysical property measurements, such as a photostationary state ratio of approximately 90/10.
• Demonstrates reversible biological activity, with the Z-photoisomer showing significant inhibition compared to the E-isomer.
• Data supports local, photoinduced control of actin dynamics in single cells, as described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Antoine Gamet via figshare.

Collection Method

Data likely generated from laboratory synthesis, photophysical characterization, in vitro assays, and molecular docking.

Freshness

Last updated 2026-04-09 01:05:11; freshness should be verified.